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基因组数据分析中涉及基因结构的问题

news 来源：原创 2025/5/11 2:57:26

探序基因肿瘤研究院整理

基因的结构：

以F5基因为例子，查看gtf文件对于这个基因的描述：

NC_000001.10 BestRefSeq transcript 169481189 169555719 . - . gene_id "F5"; transcript_id "NM_000130.5"; db_xref "GeneID:2153"; exception "annotated by transcript or proteomic data"; gbkey "mRNA"; gene "F5"; inference "similar to RNA sequence, mRNA (same species):RefSeq:NM_000130.5"; note "The RefSeq transcript has 1 substitution compared to this genomic sequence"; product "coagulation factor V"; tag "RefSeq Select"; transcript_biotype "mRNA";

NC_000001.10 BestRefSeq exon 169555467 169555719 . - . gene_id "F5"; transcript_id "NM_000130.5"; db_xref "GeneID:2153"; exception "annotated by transcript or proteomic data"; gene "F5"; inference "similar to RNA sequence, mRNA (same species):RefSeq:NM_000130.5"; note "The RefSeq transcript has 1 substitution compared to this genomic sequence"; product "coagulation factor V"; tag "RefSeq Select"; transcript_biotype "mRNA"; exon_number "1";

NC_000001.10 BestRefSeq CDS 169555467 169555624 . - 0 gene_id "F5"; transcript_id "NM_000130.5"; db_xref "CCDS:CCDS1281.1"; db_xref "GeneID:2153"; exception "annotated by transcript or proteomic data"; gbkey "CDS"; gene "F5"; inference "similar to AA sequence (same species):RefSeq:NP_000121.2"; note "The RefSeq protein has 1 substitution compared to this genomic sequence"; product "coagulation factor V preproprotein"; protein_id "NP_000121.2"; tag "RefSeq Select"; exon_number "1";

NC_000001.10 BestRefSeq start_codon 169555622 169555624 . - 0 gene_id "F5"; transcript_id "NM_000130.5"; db_xref "CCDS:CCDS1281.1"; db_xref "GeneID:2153"; exception "annotated by transcript or proteomic data"; gbkey "CDS"; gene "F5"; inference "similar to AA sequence (same species):RefSeq:NP_000121.2"; note "The RefSeq protein has 1 substitution compared to this genomic sequence"; product "coagulation factor V preproprotein"; protein_id "NP_000121.2"; tag "RefSeq Select"; exon_number "1";