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Lofexidine hydrochloride（盐酸洛非西丁）是一种选择性的α2a肾上腺素能受体（α2A-AR）激动剂。
化学性质/溶解性/储存
| 分子量 | 295.59 |
| 分子式 | C11H12Cl2N2O.HCl |
| CAS号 | 21498-08-8 |
| 中文名称 | 盐酸洛非西定 |
| 溶解性 | DMSO 90 mg/mL Water 90 mg/mL |
| 储存条件 | -20°C, dry, sealed |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
实验参考
蛋白/细胞实验
下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.3831 mL | 16.9153 mL | 33.8306 mL |
| 5 mM | 0.6766 mL | 3.3831 mL | 6.7661 mL |
| 10 mM | 0.3383 mL | 1.6915 mL | 3.3831 mL |
参考文献
[1] A Benjamin Srivastava, et al. New directions in the treatment of opioid withdrawal
[2] Amanda K Kuszmaul, et al. Lofexidine versus clonidine for mitigation of opioid withdrawal symptoms: A systematic review
[3] Saif Ur Rehman, et al. Clinical Efficacy and Safety Profile of Lofexidine Hydrochloride in Treating Opioid Withdrawal Symptoms: A Review of Literature
[4] Bennett Doughty, et al. Lofexidine: A Newly FDA-Approved, Nonopioid Treatment for Opioid Withdrawal
[5] No authors listed. Lofexidine